More on interference of N-acetylcysteine in measurement of acetaminophen
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چکیده
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منابع مشابه
N-Acetylcysteine Overdose After Acetaminophen Poisoning
N-acetylcysteine (NAC) is a drug used widely and effectively in oral and intravenous forms as a specific antidote for acetaminophen poisoning. In children considering the toxic dose of acetaminophen ingested by the patient and the body weight, the physician prescribes a specific dose of NAC. There is always a risk of iatrogenic overdose of NAC which can cause different mild to...
متن کاملN-Acetylcysteine Overdose After Acetaminophen Poisoning
N-acetylcysteine (NAC) is a drug used widely and effectively in oral and intravenous forms as a specific antidote for acetaminophen poisoning. In children considering the toxic dose of acetaminophen ingested by the patient and the body weight, the physician prescribes a specific dose of NAC. There is always a risk of iatrogenic overdose of NAC which can cause different mild to...
متن کاملEvaluation of Prothrombin Time in Acute Acetaminophen Overdose treated by N-acetylcysteine
Background: Acetaminophen (N-Acetyl-p aminophenol; APAP) is one of the most common types of analgesics. It is also the most common xneobitic reported to poison centers. This study investigates if therapeutic doses of NAC can falsely increase coagulation tests, prothrombin time (PT) and bleeding time (BT). Methods: Thirty-six APAP poisoned patients whose acetaminophen serum concentration were...
متن کاملThe Protective Effects of N-Acetl-Cysteine, Oxo-Thiazolidine-Carboxylate, Acetaminophen and Their Combinations against Sulfur Mustard Cytotoxicity on Human Skin Fibroblast Cell Line (HF2FF)
Background: Using human skin-fibroblast cell line HF2FF, the efficacy of some drugs was evaluated against sulfur mustard (SM) cytotoxicity. The drugs were the sulfhydryl containing molecule including N-acetylcysteine (NAC), 2-oxo-thiazolidine-4-carboxylate (OTC) and acetaminophen as glutathione (GSH) stimulator pathway. Methods: The protective effects of NAC (0.1 mM), OTC (1.8 mM), and acetami...
متن کاملMechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo.
N-Acetylcysteine is the drug of choice for the treatment of an acetaminophen overdose. It is thought to provide cysteine for glutathione synthesis and possibly to form an adduct directly with the toxic metabolite of acetaminophen, N-acetyl-p-benzoquinoneimine. However, these hypothese have not been tested in vivo, and other mechanisms of action such as reduction of the quinoneimine might be res...
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عنوان ژورنال:
- Clinical chemistry
دوره 45 4 شماره
صفحات -
تاریخ انتشار 1998